Dr. Hélène Munier-Lehmann
Biochemistry and screening group
Department of Structural Biology and Chemistry
Institut Pasteur
25-28 rue du docteur Roux,
F-75015 Paris
Phone: +33 1 45 68 83 81

Hélène Munier-Lehmann was trained as a chemist (ENSCP Engineer) and she obtained her Ph.D. in Biochemistry. After a postdoc at the EMBL in Heidelberg, she joined the Institut Pasteur. One important aspect of her work is to use the screening platform she has set up at the Institut Pasteur to identify research tools or chemical starting points for therapeutic applications, in particular broad- spectrum antiviral molecules and an unsuspected link between pyrimidine biosynthesis and the innate antiviral response.

  1. Munier-Lehmann H, Lucas-Hourani M, Guillou S, Helynck O, Zanghi G, Noel A, Tangy F, Vidalain PO, Janin YL (2015) Original 2-(3-Alkoxy-1H-pyrazol-1-yl)pyrimidine Derivatives as Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH). J Med Chem 58: 860-77
  2. Labesse G, Alexandre T, Vaupre L, Salard-Arnaud I, Him JL, Raynal B, Bron P, Munier-Lehmann H (2013) MgATP Regulates Allostery and Fiber Formation in IMPDHs. Structure 21: 975-85
  3. Labesse G, Benkali K, Salard-Arnaud I, Gilles AM, Munier-Lehmann H (2011) Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation. Nucleic Acids Research 39: 3458-72