Dr. Grzegorz Dubin
Malopolska Centre of Biotechnology
Jagiellonian University
Gronostajowa 7A str 30-387 Krakow
Poland
Phone: +48 126646362
grzegorz.dubinuj.edupl
www.mcb.uj.edu.pl

 

 

My adventure with protein crystallography has begun in the time of my PhD studies at the Jagiellonian University (JU) in Cracow, Poland at the group of Professor Jan Potempa and at the Max-Planck Institute for Biochemistry in Martinsried (near Munich) at the group of Professor Tad Holak, in the laboratory of Professor Robert Huber. After obtaining the PhD I established a Protein Crystallography Laboratory at the Faculty of Biochemistry, Biophysics and Biotechnology of JU and more recently an X-Ray Crystallography Laboratory at the Malopolska Centre of Biotechnology of JU. My interests have evolved from structural characterization of bacterial proteases and their inhibitors carried out using NMR and X-ray crystallography to general interest in structural biology and especially structural support of drug design using the latter technique. Currently my group is pursuing multiple topics including:

  • utilization of induced pockets in the design of inhibitors of signaling pathways relevant in cancer,
  • characterization of adapter proteins involved in intracellular receptor signaling
  • development of novel tools for characterization of the role of proteases in cell signaling,
  • collaborative projects on structure determination of various proteins, and
  • structural support for commercial drug development projects.