Prof. Gerhard Klebe
Institut für Pharmazeutische Chemie
Phillips-Universität Marburg
Marbacher Weg 6
35032 Marburg
Germany
Phone: +49-6421-28-21313
klebe(at)mailer.uni-marburg.de
www.agklebe.de

Gerhard Klebe studied chemistry at the University of Frankfurt/M, Germany, and obtained his doctorate in physical chemistry. After postdoctoral positions in crystallography (Grenoble, CNRS and ILL, France, and Univ. of Berne, Switzerland) he was responsible for molecular modeling and crystallography at BASF-AG in Ludwigshafen, Germany. In 2011 the research of his group was awarded an ERC Advanced Grant by the European Research Council on the “Chemogenomic profiling of

drug-protein binding by shape, enthalpy/entropy and interaction kinetics”. From his group about 300 scientific papers and more than 440 PDB entries emerged and he serves on the editorial board of several journals and was member of the Board of Governors of the Cambridge Crystallographic Data Centre. He organizes in two years frequency an International Workshop on New Approaches in Drug Discovery and Design and has drafted a text book on drug design pc1664.pharmazie.uni-marburg.de/wirkstoffdesign. Focus of our research group is directed toward the understanding of protein-ligand interactions, including chemical synthesis, microcalorimetry, molecular biology,crystallography, bioinformatics and software development. Internationally recognized software tools such as CoMSIA, AFMoC, DrugScore, Relibase/Cavbase or MOBILE have been developed in our laboratory. Several drug discovery projects concentrate on the discovery of leads for disease targets relevant for the third world. To obtain better insight into affinity and selectivity determining features fundamental research is performed on serine proteases (trypsin/thrombin), aldose/aldehyde reductase and several aspartyl proteases.