Dr. Matteo Gentili (GIO), Prof. Cristina Nativi (UF), Prof. Michael Sattler (HMGU)
Design, synthesis and optimization of paramagnetic tags. Hit optimization.
About the project:
My project is to design and synthetize paramagnetic tags. Those small molecules are meant to be attached to the surface of some proteins and help us getting a better insight of the protein’s motion in solution and interactions with some partners. Because the tags contain ions that are paramagnetic, they will induce changes on the magnetic environment of the protein that can be followed by NMR spectroscopy. By following and studying those changes, we can get very useful information to design inhibitors of protein-protein interaction!
I was born in Nantes, France. In 2012, I moved to Montpellier where I graduated in 2016 with a Master in “Chemistry, Biology and Health” from the National Graduate School of Chemistry, Montpellier (ENSCM). During this period, I got amazing opportunities to study and work in Italy, Germany and in Paris. Since October 2016 I have been living in Florence and I couldn’t have asked for more! When I am not in the lab I love exploring the culture and History of the region … there is always something to do!
Helmholtz Zentrum München (6 months)
List of publications:
List of posters:
Design of new paramagnetic tags for NMR Spectroscopy: A new strategy to yield fast, selective and irreversible tagging of protein. Denis M, Softley C, Cerofolini L, Gentili M, Fragai M, Popowicz G, Sattler M, Nativu C, Luchinat C New Frontiers in Structure-Based Drug Discovery, Sept. 23-25, 2019, Florence, Italy
Lanthanide binding tags – placing fragments in fast exchange using PCS. Softley C Denis M, Cerofolini L, Haeussinger D, Ravera E, Fragai M, Luchinat C, Gentili M, Popowicz G, Sattler M; EURO ISMAR, 25 - 30 Aug 2019, Berlin, Germany
Design of paramagnetic tags for NMR Spectroscopy: A new strategy to yield fast, selective and irreversible tagging of protein.Denis M, Softley C, Cerofolini L, Gentili M, Fragai M, Popowicz G, Sattler M, Nativi C, Luchinat C; EURO ISMAR, 25 - 30 Aug 2019, Berlin, Germany
“Synthesis of novel rigid paramagnetic tags for NMR Spectroscopy”, Denis M, Nativi C, Gentili M; ISOS, Corbella 2017
“The paramagnetic tagging of tcPex14 reveals insights into its behaviour in solution”, Denis M, Nativi C, Gentili M; EMBO Workshop: Challenges in Magnetic Resonance, 27 – 31 May 2018, Grossetto, Italy
List of presentations:
Giotto Biotech s.r.l
Via Madonna del Piano 6
50019 Sesto Fiorentino (FI)